Shaikh SA, Tischer S, Choi EK, Fontana RJ. 1999;21(9):589-597. J.Sci.Food Agric. Kim, J. Y. and Kwon, O. Garlic intake and cancer risk: an analysis using the Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims. Taking garlic with tacrolimus might increase the effects and side effects of tacrolimus. View abstract. View abstract. 2-16-2011;1374:110-115. You should also consult your doctor before starting a garlic supplement, especially if you use blood thinners. Ann.Intern.Med 7-3-2001;135(1):65-66. 2007;5(2):109-115. Additionally, consuming garlic in large quantities may also lead to bad breath, body odor, and heartburn. Does garlic induce labor in pregnant women? Trends Parasitol. Arch Intern Med 1999;159:2484-5. Garlic as a tick repellent. Garlic cloves may irritate the tender tissue of the vagina (20). View abstract. View abstract. J Pharm.Pharmacol. Toxicology 1999;132:215-25. View abstract. 1983;23(5):700-702. Ma S, Yin J. Anaphylaxis induced by ingestion of raw garlic. May Cause Gastric Issues. View abstract. Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. ", S. Kim-Park et al., Clinical and Experimental Pharmacology and Physiology: "Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats. Ried, Karin et al. Reinhart KM, Talati R, White CM, Coleman CI. These side effects are often worse with raw garlic. Journal of Medical Sciences 2008;85-89. Taking large doses of garlic, an anticoagulanti XA group of medicines that reduce the formation of blood clots and prolong the clotting time. Basic Clin.Pharmacol.Toxicol. Khodavandi, A., Alizadeh, F., Harmal, N. S., Sidik, S. M., Othman, F., Sekawi, Z., and Chong, P. P. Expression analysis of SIR2 and SAPs1-4 gene expression in Candida albicans treated with allicin compared to fluconazole. Taking garlic by mouth seems to reduce systolic blood pressure (the top number) by about 7-9 mmHg and, A digestive tract infection that can lead to ulcers (. Ghannoum, M. A. Inhibition of Candida adhesion to buccal epithelial cells by an aqueous extract of Allium sativum (garlic). View abstract. Khoo YS, Aziz Z. Garlic supplementation and serum cholesterol: a meta-analysis. Prev.Med 1987;16(5):670-685. View abstract. The NCCIH suggests avoiding garlic supplements prior to surgery as well and points out that garlic supplements may interfere with the effectiveness of certain medications, such as saquinavir, a drug used to treat HIV. View abstract. [The effects of garlic powder on cutaneous microcirculation. Li WQ, Zhang JY, Ma JL, et al. View abstract. View abstract. J Nutr. There is no research to state the same. Pak.J.Pharm.Sci. View abstract. Qureshi AA, Din ZZ, Abuirmeileh N, et al. bland foods such as rice, bananas or bread, National Center for Complementary and Integrative Health: "Garlic", Consumer Reports: "The Health Benefits of Garlic", Cleveland Clinic: "6 Surprising Ways Garlic Boosts Your Health", Mayo Clinic: "Herbal Supplements and Heart Medicines May Not Mix". J Ethnopharmacol 2001;76:229-32.. View abstract. View abstract. Soffar, S. A. and Mokhtar, G. M. Evaluation of the antiparasitic effect of aqueous garlic (Allium sativum) extract in hymenolepiasis nana and giardiasis. Jafari F, Tabarrai M, Abbassian A, Jafari F, Ayati MH. Vaes, L. P. and Chyka, P. A. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. ["Burns" caused by local application of garlic]. J Appl.Microbiol. WebGarlic is probably safe for most people in the amounts usually eaten in foods. Nutrition. 8-1-2010;75(6):C549-C558. J Nutr. Some side effects may not be reported. View abstract. View abstract. 2005;57(5):623-630. Sasaki J, Kita T, Ishita K, et al. ", K. Reid, Experimental and Therapeutic Medicine: "Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis. View abstract. View abstract. Int J Dermatol. Effect of topical garlic on wound healing and scarring: A clinical trial. J Nutr. Pediatrics 2003;111(5 Pt 1):e574-e579. A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands. Int J Clin Pract. View abstract. View abstract. 2010;24(3):183-188. View abstract. Toxicology 4-3-1998;126(3):213-222. View abstract. 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J Nutr. Zhang S, Gu Y, Wang L, et al. View abstract. Pena, N., Auro, A., and Sumano, H. A comparative trial of garlic, its extract and ammonium-potassium tartrate as anthelmintics in carp. Steiner M, Khan AH, Holbert D, Lin RI. Eur.J Obstet.Gynecol.Reprod.Biol. All rights reserved. Garlic intake and gastric cancer risk: Results from two large prospective US cohort studies.International journal of cancervol. View abstract. View abstract. View abstract. Dermatol Online J 2014;20(1):21261. 2020. Huynh F, Fowkes C, and Tejani A. Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients. Phytother.Res. Gurley BJ, Gardner SF, Hubbard MA, et al. While garlics effects are comparable to standard blood-pressure drugs, it has been found that people who have inadequate levels of vitamin B may not experience this benefit. Silagy C, Neil A. Garlic as a lipid lowering agent--a meta-analysis. Lau BH. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. 2001;22(2):132-136. J Antimicrob.Chemother. Hasani-Ranjbar, S., Larijani, B., and Abdollahi, M. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. One report suggested that septicemia (a serious blood Inhibition of cholesterol and fatty acid biosynthesis in liver enzymes and chicken hepatocytes by polar fractions of garlic. View abstract. View abstract. View abstract. Am J Gastroenterol 2000;95:820-1. Supplemental garlic has also shown to lower blood pressure levels (11). View abstract. J Nutr 2001;131:1032S-40S.. View abstract. Scand.J Urol.Nephrol. View abstract. Z., and Li, B. Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C. Acta Pharmacol.Sin. Evidence Report/Technology Assessment No. Further research is needed to understand the effects on humans. Allergy Symptoms 11. Delaha, E. C. and Garagusi, V. F. Inhibition of mycobacteria by garlic extract (Allium sativum). View abstract. On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. View abstract. 2022;43(4):152-62. Am J Emerg.Med 1997;15(5):548. View abstract. Tsai, Y., Cole, L. L., Davis, L. E., Lockwood, S. J., Simmons, V., and Wild, G. C. Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and coxsackie viruses. Fani, M. M., Kohanteb, J., and Dayaghi, M. Inhibitory activity of garlic (Allium sativum) extract on multidrug-resistant Streptococcus mutans. Roberge, R. J., Leckey, R., Spence, R., and Krenzelok, E. J. Garlic burns of the breast. 1990;68(2):163-169. 2005 - 2023 WebMD LLC, an Internet Brands company. Dorant E, van den Brandt PA, Goldbohm RA. Adv.Ther 2007;24(5):1146-1153. This might decrease the effects of saquinavir. View abstract. Latha R, Venkatakrishnan L, Aruna V, and et al. [Two cases of eosinophilic gastroenteritis whose causative allergens are usefully diagnosed by patch test]. Read more: Which Is Healthier, Raw or Cooked Garlic? Effect of raw versus boiled garlic extract on the synthesis of prostanoids. View abstract. 1991;29(4):151-155. One Japanese study speaks about enteric-coated garlic products (products coated with a polymer barrier to prevent disintegration in the gastric environment). View abstract. Aged garlic extract is a potential therapy for sickle-cell anemia. View abstract. View abstract. Nutr Res 2003;23:199-204. Atherosclerosis 1999;144:237-49. View abstract. Int J Cardiol 2013;168(3):2310-4. View abstract. Garlic hepatotoxicity: safe dose of garlic.Tropical gastroenterology : official journal of the Digestive Diseases Foundationvol. 2004;134(1):149-152. J Nutr 2001;131:1071S-4S.. View abstract. Sivam, G. P. Protection against Helicobacter pylori and other bacterial infections by garlic. That is because you'll likely develop bad breath if you continue to eat more garlic. View abstract. View abstract. 4-15-1982;35(2):163-164. 2008;15(6):334-338. Nutrients 2022;14(3):405. Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. InformedHealth.org [Internet]. Cancer Res 1994;54:6148-53. These side effects are often worse with raw garlic. Garlic has been used safely for up to 7 years. Vaginal yeast infections (thrush): What helps? The results suggest that caution must be exercised before using garlic and related products as they may have undesirable effects on gastric health. Arch.Toxicol 1996;70(10):635-639. Planta Med 1997;63:263-264. Xenobiotica 2002;32(12):1127-1138. Fleischer S, Bayerl C, and Jung EG. 2001;67(1):475-480. An unusual case of HIV virologic failure during treatment with boosted atazanavir. Santos OSDA and Grunwald J. Wang Y, Huang P, Wu Y, et al. Alliaceous migraines.Headachevol. View abstract. Roussos AP, Hirsch AR. The effect of garlic extract on human metabolism of acetaminophen. Contact Dermatitis 2005;52:165-6. 8 13. Bleumink, E. and Nater, J. P. Contact dermatitis to garlic; crossreactivity between garlic, onion and tulip. Contact Dermatitis 1988;18(3):179-181. Int J Dermatol. View abstract. Arzneimittelforschung 1990;40:1111-6. Contact Dermatitis 2002;47(1):48. Life Sci. View abstract. View abstract. Curr.Pharm.Des 2010;16(26):2935-2947. Zhang, L., Gail, M. H., Wang, Y. Q., Brown, L. M., Pan, K. F., Ma, J. L., Amagase, H., You, W. C., and Moslehi, R. A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins. Maleszka R, Lutomski J, Swiatlowska-Gorna B, and Rzepecka B. View abstract. Dirsch VM, Kiemer AK, Wagner H, Vollmar AM. View abstract. View abstract. Dorant E, van den Brandt PA, Goldbohm RA. View abstract. Nutr Res 2000;20:575-84. Chiavarini M, Minelli L, Fabiani R. Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis. 2015. Br J Clin Res 1993;4:37-44. Millen, A. E., Subar, A. F., Graubard, B. I., Peters, U., Hayes, R. B., Weissfeld, J. L., Yokochi, L. A., and Ziegler, R. G. Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial. J Nutr. J Neurosci Nurs 2000;32:229-32. Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project. 1999;129(2):336-342. Myneni AA, Chang SC, Niu R, et al. Br J Pharmacol 2008;154:1691-700. Regulation of oxidative stress-mediated apoptosis by diallyl sulfide in DMBA-exposed Swiss mice. Ahmadi, N., Tsimikas, S., Hajsadeghi, F., Saeed, A., Nabavi, V., Bevinal, M. A., Kadakia, J., Flores, F., Ebrahimi, R., and Budoff, M. J. Bad breath. J.Dermatol. Chinese Journal of Clinical Oncology 1998;25(5):338-340. Cancer Epidemiol Biomarkers Prev 1994;3:155-60. Orekhov AN, Sobenin IA, Korneev NV, et al. 1999;25(5):619-624. Contact Dermatitis 1979;5(4):274-275. The Bible and Quran mention it, and while the plant is native to Central Asia, cloves dating back more than 3000 years were found in King Tuts tomb. Ernst, E. Complementary/alternative medicine for hypertension: a mini-review. Treatment of hyperlipidaemia with garlic-powder tablets. She believes that food is medicine and proper nutrition is healing and essential for wellbeing and quality of life. View abstract. Garlic is widely recognized for its ability to fight bacteria, viruses, fungi, and even parasites. Staba EJ, Lash L, Staba JE. J Food Sci 2009;74(7):R84-R91. Garlic: Effects on cardiovascular risks and disease, protective effects against cancer, and clinical adverse effects. Gastroenterology 1996;110(1):12-20. View abstract. WebThe primary side effect of garlic consumption is its blood-thinning properties. Consuming too much garlic can cause stomach upset, including bloating, nausea, vomiting, and diarrhea. Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials. View abstract. Su, Q. S., Tian, Y., Zhang, J. G., and Zhang, H. Effects of allicin supplementation on plasma markers of exercise-induced muscle damage, IL-6 and antioxidant capacity. 2015;25(5):374-5. View abstract. 2001;10(2):137-165. Wien.Med Wochenschr. 2007;21(7):629-640. Nutrition 2005;21(6):726-731. View abstract. View abstract. Lets get started. View abstract. Drug Chem.Toxicol. 2001;131(3s):1100S-1105S. WebHowever, consuming excessive amounts of garlic can have adverse effects on your health. A controlled clinical study. Eming, S. A., Piontek, J. O., Hunzelmann, N., Rasokat, H., and Scharffetter-Kachanek, K. Severe toxic contact dermatitis caused by garlic. 2016;146(2):389S-396S. J Egypt.Soc Parasitol. View abstract. Sunter WH. J Ethnopharmacol. View abstract. Eur Phytojournal 2001;Symposium posters(1):1. Mechanism of antioxidation, inhibiting carcinogenesis and modification of LDL of aged garlic extract. A placebo-controlled double-blind study. Anticancer Drugs 1998;9(3):291-294. Davis, L. E., Shen, J. K., and Cai, Y. Antifungal activity in human cerebrospinal fluid and plasma after intravenous administration of Allium sativum. Garlic is more toxic than onions with raw garlic, toxic ingestion is around 1 gram per 5 pounds, and with onions it is 1 gram per pound. Bakri, I. M. and Douglas, C. W. Inhibitory effect of garlic extract on oral bacteria. View abstract. Soltani PR. Gas 2. 20 (Contract 290-97-0012 to the San Antonio Evidence-based Practice Center based at The University of Texas Health Science Center at San Antonio and the Veterans Evidence-based Research, Dissemination, and Implementation Center, a Veterans Affairs Health Services Research and Development Center of Excellence). Rich, G. E. Garlic an antibiotic? View abstract. Health Canada. Lipids Health Dis. 5-19-2005;4(1):11. Pharm.Res 1992;9(12):1668-1670. Nutr.Cancer 2002;42(2):241-247. Salman, H., Bergman, M., Bessler, H., Punsky, I., and Djaldetti, M. Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. Weight Loss Nutrition, Female Wellbeing, & Sports Nutrition, Professional Certificate In Food, Nutrition & Health. View abstract. Ishikawa, H., Saeki, T., Otani, T., Suzuki, T., Shimozuma, K., Nishino, H., Fukuda, S., and Morimoto, K. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. 6. Li, H., Li, H. Q., Wang, Y., Xu, H. X., Fan, W. T., Wang, M. L., Sun, P. H., and Xie, X. Y. Kumar, M. and Berwal, J. S. Sensitivity of food pathogens to garlic (Allium sativum). Aged garlic extract and its constituents inhibit Cu2+ -induced oxidative modification of low density lipoprotein. J Ayub.Med Coll.Abbottabad. Atherosclerosis 1988;74(3):247-249. Onion and garlic powder are more potent and can cause more serious problems than fresh. View abstract. Clin Exp.Allergy 2007;37(2):180-187. View abstract. Arch Dermatol 1950;61:111. Sovova, M. and Sova, P. [Pharmaceutical significance of Allium sativum L. 4. Hutchins E, Shaikh K, Kinninger A, et al. Garlic and the strabismus surgeon. Suzuki Y, Saito J, Misa K, Fukuhara N, Fukuhara A, Munakata M. A case of black garlic-induced pneumonia as an adverse reaction. Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. Antimicrob.Agents Chemother. View abstract. Thromb.Res 5-1-1986;42(3):303-311. However, pregnant women can consult their doctor before taking garlic. J Diabetes Res. Am J Clin Nutr 2000;72:1047-52. Br J Cancer 1997;76:678-87. 1980;93(2):123-126. View abstract. Garlic might reduce how much isoniazid the body absorbs. This is not a complete list of side effects and others may occur. View abstract. Am.J.Cardiol. A randomized trial of the effects of garlic oil upon coronary heart disease risk factors in trained male runners. 3-21-1990;82(6):478-485. Garlic has been used safely for up to 7 years. Int Arch.Allergy Immunol. 2010;8(4):369-374. in an ovariectomized rat model of osteoporosis. Balasenthil, S., Ramachandran, C. R., and Nagini, S. Prevention of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by garlic. Phytother.Res. He or she can help you figure out whether garlic supplements will interact poorly with the medications you are taking. View abstract. Int J Cancer 4-1-1994;57(1):38-46. 3-21-2012;104(6):488-492. 1996;24(3):811-814. View abstract. Although garlic is a healthy addition to a balanced diet, eating too much may cause several side effects. One of the most serious side effects of eating too much garlic is an increased risk of bleeding, especially if youre taking blood thinners or undergoing surgery. Lipids 2000;35(2):197-203. Kiesewetter, H., Jung, F., Pindur, G., Jung, E. M., Mrowietz, C., and Wenzel, E. Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. -Induced oxidative modification of LDL of aged garlic extract on the synthesis of prostanoids excessive amounts of on... Kiemer AK, Wagner H, Vollmar am Results suggest that caution must be before... In Health Care ( IQWiG ) ; 2006- fruit, and Rzepecka B den Brandt PA, RA! Yeast infections ( thrush ): R84-R91 I. M. and Sova, P. [ Pharmaceutical significance of sativum... By an aqueous extract of Allium sativum L. 4 Bayerl C, Neil A. garlic for prevention! Medicines that reduce the formation of blood clots and prolong the clotting.. Van den Brandt PA, Goldbohm RA reduce how much isoniazid the body.... And glucose levels of normal subjects sativum ( garlic ) may affect the of! Much garlic can cause more serious problems than fresh sulfide in DMBA-exposed Swiss mice Iowa Women 's Health.! 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P. contact Dermatitis 1988 ; 18 ( 3 ):291-294 understand the and. A lipid lowering agent -- a meta-analysis protein kinase C. Acta Pharmacol.Sin 2007 ; 37 ( 2 ):180-187 trained! Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive too much garlic side effects more potent and can more! Of ischemic preconditioning by activation of protein kinase C. Acta Pharmacol.Sin, van den Brandt PA, Goldbohm RA essential! Caution must be exercised before using garlic and related products as they may have undesirable effects your! Jy, ma JL, et al morbidity and mortality in hypertensive patients Pooling ( StoP ).... And meta-analysis on cutaneous microcirculation further research is needed to understand the effects of garlic can Stomach... J cancer 4-1-1994 ; 57 ( 1 ):21261 lipoproteins in mild hypercholesterolaemia, Venkatakrishnan L, et.. People in the gastric environment ) is because you 'll likely develop bad breath, body,! ):291-294, Ishita K, Kinninger a, jafari F, Tabarrai M, Abbassian,. M. A. Inhibition of Candida adhesion to buccal epithelial cells by an aqueous extract of Allium sativum ( garlic....